[18F]FTC-146 PET/MRI in Healthy Volunteers and in CRPS and Sciatica
Status:
Completed
Trial end date:
2017-02-16
Target enrollment:
Participant gender:
Summary
Chronic pain can result from injured or inflamed nerves, as occurs in people suffering from
sciatica and CRPS. These nerve injuries or regions of nerve irritation are often the cause of
pain in these conditions, but the current diagnostic tools are limited in pinpointing the
area of origin. Several studies have implicated involvement of sigma-1 receptors in the
generation and perpetuation of chronic pain conditions, others are investigating anti sigma-1
receptor drugs for the treatment of chronic pain. Using the sigma-1 receptor (S1R) detector
and experimental radiotracer [18F]FTC-146 and positron emission tomography/magnetic resonance
imaging (PET/MRI) scanner, the researchers may potentially identify the source of pain
generation in patients suffering from complex regional pain syndrome (CRPS) and chronic
sciatica. The ultimate goal is to assist in the optimization of pain treatment regimens using
an [18F]FTC-146 PET/MRI scan.
The study is not designed to induce any physiological/pharmacological effect.